A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones.
نویسندگان
چکیده
A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
منابع مشابه
Metal-free oxysulfenylation of alkenes with 1-(arylthio)pyrrolidine-2,5-diones and alcohols.
β-Alkoxy sulfides are widely used as versatile building blocks in organic synthesis. Therefore, it is highly desirable to develop a convenient and efficient method for oxysulfenylation of alkenes. In this communication, an easy and efficient metal-free approach to β-alkoxy sulfides has been developed. The protocol uses readily available 1-(arylthio)pyrrolidine-2,5-diones and alcohols as the oxy...
متن کاملA Simple, Practical and Efficient Method for the Synthesis of New Disubstituted 1,3,4-oxadiazoles
Reactions of N-isocyaniminotriphenylphosphorane with α- chloroketones in the presence ofaromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions toafford new disubstituted 1,3,4-oxadiazole derivatives in high yields.
متن کاملKinetic resolution of racemic pyrrolidine-2,5-diones using chiral oxazaborolidine catalysts.
Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol.
متن کاملEfficient Synthesis of 5,5-Disubstituted Bis-hydantoins/spirohydantoins and a Tetrakis-analogue: A Drug-like Multi-cyclic Scaffold
An easy method was developed for the efficient preparation of diversely new 5,5-disubstituted N(3),N'(3)-linkaged bis-hydantoins. At first, using the same methods, some ketones and terephthalaldehyde were converted to several hydantoins and a new bis-hydantoin , respectively. Then 1,6-dibromohexane, as a mild reagent, was employed for the alkylation and incorporation of synthesized substrates t...
متن کاملDBU As A Novel and Highly Efficient Catalyst for The Synthesis of 3,5-Disubstituted-2,6-dicyanoanilines Under Conventional and Microwave Conditions
3,5-disubstituted-2,6-dicyanoaniline derivatives have been synthesized via the reaction of aryl methylene- and 1-arylethylidenemalonodinitriles using 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 17 5 شماره
صفحات -
تاریخ انتشار 2012